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5-Aminosalicylic acid

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Formula: C7H7NO3
CAS: 89-57-6
search Element: aminosalicylic acid

Identification

Structural Formula
5-Aminosalicylic acid
CAS:
89-57-6
EINECS:
201-919-1
Molecular Formula:
C7H7NO3
MDL:
MFCD00007877
SMILES:
NC1=CC(C(O)=O)=C(O)C=C1
Synonym:
mesasal ; 5-as ; pentasa ; canasa ; 5-asa ; asalit ; asacol ; ipocol ; rowasa ; lixacol


Description

5-Aminosalicylic Acid, the metabolite of sulphasalazine, has been shown to inhibit PGDH (prostaglandin 15-hydroxydehydrogenase) in human placenta and bovine lung. Further studies show that this antiinflammatory compound also inhibits leukotriene formation in human leukocytes. Additionally, 5-Aminosalicylic acid demonstrates the ability to disrupt TNFα (tumor necrosis factor α)-stimulated NFκB (nuclear factor κB) activation via inhibition of the multimeric IκB kinase regulating complex.


Suppliers

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Shandong Minglang Chemical Co., Ltd
SMC14705880
H&Z Industry Co.,Ltd
HIC8403360
Krada CPS Industry S.L
KCIS9244620
Wuhan PharmChem Co., LTD.
WP10503150
Shandong SanYoung Industry Co., Ltd
SSI14705880
Indofine Chemical Co, Inc.
06-1374
Xiamen Equation Chemical Co.,Ltd
XECC13446720
Hainan Zhongxin Chemical Co., Ltd.
HZC14285712
Daming Changda Co., Ltd.
DC10083024
Aecochem Corp.
AC5881764
CSNpharm, Inc.
CSN13074
Hangzhou Keying Chem Co., Ltd.
HKC12605040
Sigma-Aldrich International GmbH
SI13444032
scienTEST - bioKEMIX GmbH
S-B10504200
Finetech Industry Limited
FIL10504200
Carbone Scientific Co., Ltd.
CS11763528
Hefei Hirisun Pharmatech Co., Ltd
HR130609
AK Scientific, Inc.
AS7982394
Simagchem Corporation
SC8822646
Xingrui Industry Co., Limited
XIL12184872
Leap Chem Co., Ltd
LC7562268
Santa Cruz Biotechnology, Inc.
202890
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Prices & Availability




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Properties for 5-Aminosalicylic acid

Molecular Weight:
153.14 g·mol−1
Density:
1.57 g/cm3
Melting point:
275-280 °C (dec.)(lit.)
Boiling point:
403.86° C at 760 mmHg (Predicted)
Flash point:
279-281 °C
Solubility:
Soluble in 1 M hydrochloric acid (50 mg/ml), water (0.84 g/l at 20° C), alcohol, DMSO (~4 mg/ml), DMF (~1.6 mg/ml), PBS(pH=7.2) (~1.7 mg/ml), methanol, water (1.7 mg/ml at 25° C), and ethanol (31 mg/ml at 25° C). Insoluble in diethyl ether, and n-octanol.
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Classes:
irritant
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
2-8°C
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Alternative Distributors of [5-Aminosalicylic acid]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | DKSH International AG | Advance Scientific & Chemical, Inc. | BOC Sciences | ABCR GmbH & Co. KG | Qingdao Sunrisechem Co., Ltd. | Hefei Photochem Trading Co., Ltd | Jinan Great Chemical Co., Ltd. | Gihi Chemicals Co., Limited | ForeChem Ltd. | Rongkang Industry Co.,Ltd - (NSTU Chemicals Hanggzhou Co.,) | Watson International Ltd | Syntese A/S | TCI Europe NV | Ubichem PLC | Molekula GmbH | Shanghai ChemVia Co., Ltd | scienTEST | Jinan Haohua Industry Co., Ltd. | Green Fine Chemical (Shanghai) Co., Ltd. | Taizhou Huading Chemical Co., Ltd. | Clearsynth Canada INC. | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai AOKChem Group Limited | Hangzhou Sida Organic Chemical Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Shanghai Chemsors chemicals Co., Ltd. | Haihang Industry Co., Ltd. | QiHui Pharmtech & Chemical Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Shanghai Arbor Chemical Co., Ltd. | D.K.Pharmachem Pvt Ltd. | Jinjiangchem Corporation | Chemwing (Shanghai) Co., Ltd. | Shanghai Raise Chemical Technology Co., Ltd. | Chemwill Asia Co.,Limited | Hubei Yuancheng Saichuang Tech.Co.,Ltd

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