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Butein

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Formula: C15H12O5
CAS: 487-52-5
search Element: butein

Identification

Structural Formula
Butein
CAS:
487-52-5
EINECS:
207-659-5
Molecular Formula:
C15H12O5
MDL:
MFCD00017300
SMILES:
C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O)O
Synonym:
butein(p) ; 2',3,4,4'-tetrahydrochalcone ; butein with hplc ; butein(sh) ; einecs 207-659-5 ; butanol ; 2',3,4,4'-tetrahydroxychalcone ; (2e)- ; butein ; 3,4,2',4'-tetrahydroxychalcone


Description

Butein is a plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Butein potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 μM) and p60c-src (IC50 = 65 μM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and antiinflammatory agent which has been shown to inhibit glutathione reductase and rat liver GST (glutathione-S-transferase (IC50 = 9 μM)). Butein has been reported to activate sirtuins and promote the survival of eukaryotic cells. The Sirtuins, SIRT1-4 and SIRT7 are deacetylases relevant to histone modification. Butein directly inhibits IKK and suggested to also display inhibition towards PDE (c-AMP dependent PDE-IV). Also a potential CYP19 (Aromatase) inhibitor.


Suppliers

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Sigma-Aldrich International GmbH
SI192576
Leap Chem Co., Ltd
LC108324
Santa Cruz Biotechnology, Inc.
202510
Dayang Chem (Hangzhou) Co.,Ltd.
DC186744
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CAS equal suppliers

butein with hplc
Indofine Chemical Co, Inc.
021103S
(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
R&D Scientific Inc.
RS1273038190

Prices & Availability




Data is processed


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Properties for Butein

Molecular Weight:
272.25 g·mol−1
Density:
1.48 g/cm3 (Predicted)
Melting point:
216 °C
Boiling point:
560.92° C at 760 mmHg (Predicted)
Solubility:
DMSO: >50 mg/mL
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Safety & Transport Information

Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
Storage temperature :
-20°C
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Alternative Distributors of [Butein]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ABCR GmbH & Co. KG | SYNCHEM OHG | Carl Roth GmbH + Co KG | Shanghai Tauto Biotech Co., Ltd. | Shanghai Witofly Chemical Co., Ltd. | BioBioPha Co., Ltd. | Jinan Haohua Industry Co., Ltd.

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Downloads

Mol File:
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MSDS:
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