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Harpagoside

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Formula: C24H30O11
CAS: 19210-12-9
search Element: harpagoside

Identification

Structural Formula
Harpagoside
CAS:
19210-12-9
EINECS:
242-881-6
Molecular Formula:
C24H30O11
MDL:
MFCD00017415
SMILES:
CC1(CC(C2(C1C(OC=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O)OC(=O)C=CC4=CC=CC=C4
Synonym:
harpogoside ; harpagoside with hplc ; harpagoside hplc ; einecs 242-881-6 ; 8'-cinnamoylharpagide ; harpagoside ,98% ; harpagoside ; harpagoside(p) ; harpagosid ; 8-o-e cinnamoyl harpagide


Description

Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil's Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside.


Suppliers

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Aozeal Certified Standards (AOCS), Inc.
H0066.00
Chengdu Pufeide Biotech. Co., Ltd
CPB3631452
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI7593036
Xiamen Equation Chemical Co.,Ltd
XECC3521760
CSNpharm, Inc.
CSN16185
Sigma-Aldrich International GmbH
SI3521056
Finetech Industry Limited
FIL2751100
Pharmacore Co., Limited
PL253759
Simagchem Corporation
SC231693
BOC Sciences
BS132396
Leap Chem Co., Ltd
LC198594
Santa Cruz Biotechnology, Inc.
203073
Dayang Chem (Hangzhou) Co.,Ltd.
DC3411364
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CAS equal suppliers

harpagoside with hplc
Indofine Chemical Co, Inc.
020229S
b-D-Glucopyranoside,(1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl
Xingrui Industry Co., Limited
XIL105792423168

Prices & Availability




Data is processed


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Properties for Harpagoside

Molecular Weight:
494.49 g·mol−1
Melting point:
120 °C (dec.)
Solubility:
Soluble in methanol.
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
Safety Codes:
S22 - Do not breathe dust
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8 °C
RID/ADR certification :
3172
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Alternative Distributors of [Harpagoside]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ABCR GmbH & Co. KG | East Chemical Industry Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Jinan Great Chemical Co., Ltd. | Carl Roth GmbH + Co KG | Cfm Oskar Tropitzsch GmbH | BOC Sciences | Xiamen Hisunny Chemical Co., Ltd. | Gihi Chemicals Co., Limited

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MSDS:
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