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Indomethacin

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Formula: C19H16ClNO4
CAS: 53-86-1
search Element: indomethacin

Identification

Structural Formula
Indomethacin
CAS:
53-86-1
EINECS:
200-186-5
Molecular Formula:
C19H16ClNO4
MDL:
MFCD00057095
SMILES:
COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O
Synonym:
tannex ; vonum ; indacin ; lausit ; dolovin ; inacid ; amuno ; indocin ; catlep ; bonidin


Description

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.


Suppliers

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Krada CPS Industry S.L
KCIS2641320
Shandong SanYoung Industry Co., Ltd
SSI4201680
H&Z Industry Co.,Ltd
HIC240960
Nantong Xindao Biotech Ltd
NXB3121248
Aozeal Certified Standards (AOCS), Inc.
I0006.00
FUDI Chemical Co. Ltd.
FCC2641056
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI8283312
Shandong Minglang Chemical Co., Ltd
SMC4201680
Gyma Laboratories Of America, Inc.
GLOA4082040
Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT6123060
CellMark AB
CA132396
X´ian Taicheng Chem Co., Ltd
XTC3481392
Hangzhou Verychem Science & Technology Co., Ltd.
HVST5762880
Xiamen Equation Chemical Co.,Ltd
XECC3841920
Aecochem Corp.
AC168504
scienTEST - bioKEMIX GmbH
S-B3001200
Carbone Scientific Co., Ltd.
CS3361008
AK Scientific, Inc.
AS228684
Xingrui Industry Co., Limited
XIL3481392
Santa Cruz Biotechnology, Inc.
200503
Dayang Chem (Hangzhou) Co.,Ltd.
DC3721488
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Prices & Availability




Data is processed


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Properties for Indomethacin

Molecular Weight:
357.79 g·mol−1
Density:
1.33 g/cm3
Melting point:
155-162 °C
Solubility:
ethanol: 50 mg/mL, clear, yellow-green
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Hazard Statements

GHS06

GHS06
Toxic
  • Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

Risk Codes:
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R28 - Very toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28 - After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1
Hazard Symbols:
T+, Xi, T
Hazard symbol T Hazard symbol Xi Hazard symbol T+
Storage temperature :
Store at RT
RID/ADR certification :
UN 2811 6.1 / PG 1
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Alternative Distributors of [Indomethacin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Santec Chemicals Corp. | Molekula GmbH | Hallochem Pharma Co., Ltd. | Jiangsu Guotai International Group Co., Ltd. | Xiang Ding Chemical International Co., Ltd | ABCR GmbH & Co. KG | Nantong Chem-Tech. (Group) Co., Ltd. | Ningbo Pangs Chem Int'l Co., Ltd. | TCI Europe NV | China Yangzhou Wandong Medical Co., Ltd. | Changzhou An-Yuan Imp. & Exp. Corporation | New Dragon Industrial Co., Ltd | Discovery Fine Chemicals Limited | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai AOKChem Group Limited | Lanospharma Laboratories Co., Ltd. | Jinan Great Chemical Co., Ltd. | Shanxi Zishan Natural Technology Co., Ltd. | Suzhou Sibian Chemical Technology Co., Ltd. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | Cfm Oskar Tropitzsch GmbH | Watson International Ltd | BOC Sciences | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Changzhou Sunsanta Trading Co., Ltd | Jinan Haohua Industry Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Clearsynth Canada INC. | Green Fine Chemical (Shanghai) Co., Ltd. | scienTEST | Yangzhou Princechem Co., Ltd. | Haihang Industry Co., Ltd.

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