Lovastatin | CAS 75330-75-5 | Chemical-Suppliers

Element: lovastatin

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C-S » Chemicals » lovastatin-PX72365

Identification

Lovastatin

CAS:

75330-75-5

EINECS:

Molecular Formula:

C₂₄H₃₆O₅

MDL:

MFCD00072164

SMILES:

CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

Synonym:

mevinolin ; paschol ; rovacor ; mk-803 ; msd803 ; mevacor ; sivlor ; mevlor ; lovastin ; lovalip

Description

Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. Lovastatin inhibits HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells expressing activated p21ras oncoprotein - the posttranslational isoprenylation of the p21ras with mevalonate is crucial for translocation and membrane adhesion of the protein, and blockade of this modification by Lovastatin-induced depletion of cellular mevalonate leads to suspension of cell progress. The signaling activity of epidermal growth factor (EGF) and insulin-like growth factor (IGF-I) are similarly affected by impairment of mevalonate-dependent protein prenylation. Induction of apoptosis by Lovastatin in malignant mesothelioma cells is also ascribed to the inhibition of mevalonate synthesis and posttranslational protein modifications. Lovastatin is a substrate of CYP and Mdr-1.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Shandong SanYoung Industry Co., Ltd

SSI3501400

Ambeed, Inc.

A151986

Indofine Chemical Co, Inc.

Bio-858

ACIC Fine Chemicals Inc.

AFC240960

INDAM Inc.

I100200

ICC Chemical Corporation

ICC240960

Xiamen Equation Chemical Co.,Ltd

XECC3201600

Aecochem Corp.

AC140420

CSNpharm, Inc.

CSN11335

Hangzhou Lingrui Chemical Co., Ltd.

HLC3501400

Wanko Chemical Co., Ltd.

WC240720

Sigma-Aldrich International GmbH

SI320960

scienTEST - bioKEMIX GmbH

S-B2501000

Carbone Scientific Co., Ltd.

CS280840

Acinopeptide Co., Ltd.

A220440

Iris Biotech GmbH

LS-1038.0000

AK Scientific, Inc.

AS190570

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

200850

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CAS equal suppliers

Lovalip

Hangzhou J&H Chemical Co., Ltd.

HJC217868

Lovastatin, 97%

Alfa (A Johnson Matthey Company)

A4801440

Lovastatin, Mevinolin

Iris Biotech GmbH

LS-1038

Red Yeast Rice Extract

Gihi Chemicals Co., Limited

GCL23769504

Simvastatin EP impurity E

Salsbury Chemicals, Inc.

SC24007200

Lovastatin (Simvastatin EP Impurity E)

Aozeal Certified Standards (AOCS), Inc.

S0002.05

(S)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate

BLD Pharmatech Ltd

BP62514187542

Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-

Gihi Chemicals Co., Limited

GCL114075456300

Prices & Availability

Data is processed

Properties for Lovastatin

Molecular Weight:

404.54 g·mol−1

Density:

~1.1 g/cm³ (Predicted)

Melting point:

175 °C

Boiling point:

~559.2° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Classes:

Hazard Symbols:

Storage temperature :

2-8°C

RID/ADR certification :

3077

Alternative Distributors of [Lovastatin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified