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R-(-)-Rolipram

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Formula: C16H21NO3
CAS: 85416-75-7
search Element: rolipram
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Identification

Structural Formula
R-(-)-Rolipram
CAS:
85416-75-7
EINECS:
Molecular Formula:
C16H21NO3
MDL:
MFCD03093860
SMILES:
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
Synonym:
(4r)-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ; rolipram (r)-(-)- ; 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one ; (r)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ; (r)-(-)-rolipram ; (4s)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ; (r)-rolipram ; (4r)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one ; 4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone ; (4r)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ; 2-pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (r)- ; (s)-(+)-rolipram


Description

R-(-)-Rolipram is the R-entantiomer of rolipram. This compound has been shown to strongly inhibit the catalytic activities of PDE4 (phosphodiesterase 4), which is selective for cAMP, an important secondary messenger molecule in signal transduction. Experiments have revealed that high-affinity binding sites require residues within the catalytic domains and residues flanking the N-/C-terminal to the catalytic region of amino acids. Other studies suggest that the deactivation of PDE4 has been reported to affect other cellular functions.


Suppliers

Santa Cruz Biotechnology, Inc.
201199
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Prices & Availability




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Properties for R-(-)-Rolipram

Molecular Weight:
275.34 g·mol−1
Density:
1.155 g/cm3
Melting point:
132.2° C
Boiling point:
472.7 °C at 760 mmHg
Flash point:
239.7 °C
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Hazard Classes:
irritant
Storage temperature :
Store at RT
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Alternative Distributors of [R-(-)-Rolipram]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | Abcam Biochemicals plc (formaly Ascent Scientific Ltd.) | Changzhou Weijia Chemical Co.,Ltd. -WJCHEM-

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Downloads

Mol File:
-/-
MSDS:
-/-




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