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Suramin Sodium

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Formula: C51H34N6Na6O23S6
CAS: 129-46-4
search Element: suramin sodium
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Identification

Structural Formula
Suramin Sodium
CAS:
129-46-4
EINECS:
204-949-3
Molecular Formula:
C51H34N6Na6O23S6
MDL:
MFCD00210217
SMILES:
CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Synonym:
309f ; naganol ; antrypol ; bayer205 ; bay205 ; f-309 ; nf060 ; naganin ; moranyl ; suramin


Description

Suramin Sodium uncouples G proteins from receptors by blocking their interaction with intracellular, P2X and P2Y, purinergic receptor domains. The compound also inhibits the cell surface binding of various growth factors including PDGF, FGF-2 (FGFb), FGF-1 (FGFa), EGF and TGF-β. It is a potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection. Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 μM along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF.


Suppliers

H&Z Industry Co.,Ltd
HIC5602240
+
Finetech Industry Limited
FIL7002800
+
Capot Chemical Co., Ltd.
36339
+
Leap Chem Co., Ltd
LC5041512
+
Santa Cruz Biotechnology, Inc.
200833
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Alfa (A Johnson Matthey Company)
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8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfoni
Gihi Chemicals Co., Limited
GCL29160116640

Prices & Availability




Data is processed


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Properties for Suramin Sodium

Molecular Weight:
1429.17 g·mol−1
Solubility:
H2O: >10mg/mL
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Safety & Transport Information

Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
Storage temperature :
0-6°C
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Alternative Distributors of [Suramin Sodium]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | Jinan Great Chemical Co., Ltd. | Lanospharma Laboratories Co., Ltd. | East Chemical Industry Co., Ltd.

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