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Swainsonine

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Formula: C8H15NO3
CAS: 72741-87-8
search Element: swainsonine
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Identification

Structural Formula
Swainsonine
CAS:
72741-87-8
EINECS:
Molecular Formula:
C8H15NO3
MDL:
MFCD00017554
SMILES:
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
Synonym:
1,2,8-indolizinetriol,octahydro-, [1s-(1a,2a,8b,8ab)]- ; swainsonine min. 99% ; swainsonine 98+% ; d-swainsonine ; (-)-swainsonine ; (1s,2r,8r,8ar)-octahydro-1,2,8-indolizinetriol ; 8a,b-indolizidine-1,2a,8b-triol ; swainsonine synthetic ; 1,2,8-indolizinetriol, octahydro-, (1s,2r,8r,8ar)- ; 1,2,8-indolizinetriol,octahydro-, (1s,2r,8r,8ar)- ; swainsonine ; swainsonine from locoweed ; (-)-d-swainsonine ; (1s,2r,8r,8ar)-octahydroindolizine-1,2,8-triol ; swainmoia ; tridolgosir


Description

Swainsonine, an indolizidine alkaloid, has been shown to inhibit the breakdown of glycoprotein by rat liver lysosomes and also suppress MAN2A1 (Golgi mannosidase II). This compound has been reported to be a potent antiproliferative and immunomodulatory agent via stimulation of lymphocyte proliferation. Additionally, Swainsonine displays the ability to inhibit MAN2B1 (lysosomal α-mannosidase) and MAN2C1. Mechanistic studies suggest that this agent can alter carbohydrate processing of β-galactosidase and β-glucuronidase.


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Santa Cruz Biotechnology, Inc.
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Properties for Swainsonine

Molecular Weight:
173.2096 g·mol−1
Density:
1.38 ±0.1 g/cm3 (20 °C 760 Torr)
Melting point:
148-149 °C
Boiling point:
353.302 °C at 760 mmHg
Flash point:
209.735 °C
Solubility:
Soluble in 100% ethanol, DMSO, methanol, water (10 mg/ml), DMF (~10 mg/ml), and PBS (pH=7.2) (0.25 mg/ml).
Physical Description:
white crystalline solid
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Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
Safety Codes:
S36 - Wear suitable protective clothing
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [Swainsonine]

Producers or manufacturers change the product range from time to time. The following companies
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MSDS:
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