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HA14-1

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Formula: C17H17BrN2O5
CAS: 65673-63-4
search Element: ha14

Identification

Structural Formula
HA14-1
CAS:
65673-63-4
EINECS:
Molecular Formula:
C17H17BrN2O5
MDL:
MFCD00218213
SMILES:
CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N
Synonym:
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-1-benzopyran-3-carboxylate 97% ; 2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(4h)-1-benzopyrane-4-aceticacidethylester ; 2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-4h-1-benzopyran-4-acetic acid ethyl ester ; ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4h-chromene-3-carboxylate ; 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4h-1-benzopyran-4-aceticacidethylester ; ha14-1 ; (r)-ethyl 2-amino-6-bromo-4-((r)-1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate ; ethyl 6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate ; ethyl2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-1-benzopyran-3-carboxylate97% ; [ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4h-chromene3-3carboxylate]


Description

HA14-1 is a small, cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action. HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.


Suppliers

Aea.ltd
A84168
CSNpharm, Inc.
CSN11133
Santa Cruz Biotechnology, Inc.
205911
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CAS equal suppliers

HA 14-1
Leap Chem Co., Ltd
LC252756
HA 14-1
Santa Cruz Biotechnology, Inc.
SCB4201680
Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4-H-chromene-3-carboxylate
Manchester Organics Limited
C25765

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Properties for HA14-1

Molecular Weight:
409.23 g·mol−1
Density:
1.480
Melting point:
105 °C
Boiling point:
535.1° C at 760 mmHg
Solubility:
DMSO: 26 mg/mL
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Safety & Transport Information

Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
Storage temperature :
-20°C
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Alternative Distributors of [HA14-1]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | Excenen Pharmatech Co., Ltd. | D&P Global Chemical Co., Ltd

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