E-64

E-64 is a broad spectrum cysteine proteinase and calpain activation inhibitor. E-64 has been reported to inhibit intracellular cathepsin B, cathepsin L, cathepsin H, Bax protease activity, and reduces oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP acitivity. Additionally, Prevotella intermedia studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S.