SU6656

SU6656 is a small-molecule, indolinone which potently and selectively inhibits Src tyrosine kinases, which are known to function in signal transduction pathways. Investigators show that SU6656 causes proliferation abrogation in non-Hodgkin's lymphoma cell lines and induces megakaryocytic progenitor cell maturation with increased FUT8 fucosyltransferase activity. Further research shows that SU 6656 induced Src tyrosine kinase inhibition attenuates radiation induced Akt phosphorylation, increases radiation-induced apoptosis and increases vascular endothelium destruction in human umbilical vein endothelial cells. This inhibitor serves as a useful tool in elucidating molecular components of cellular signal transduction pathways. SU6656 inhibits c-Src (Src)(IC₅₀ = 280 nM), Fyn (IC₅₀ = 170 nM), c-Yes (IC₅₀ = 20 nM), Lyn (IC₅₀ = 130 nM),Lck (IC50 = 688 μM) and PDGF receptor kinase (IC50 >10μM).