ag 490 ; n-benzyl-3,4-dihydroxy-alpha-cyanocinnamide ; a-cyano-(3,4-dihydroxy)-n-benzylcinnamide ; tyrophostin ag490 ; tyrphostin ag 490 ; a-cyano-(3,4-dihydroxy)-n-benzylcinnamamide ; tyrphostin b42 ; tyrphostin ag 490, 99+% ; alpha-cyano-(3,4-dihydroxy)-n-benzylcinnamide ; ag 490, tryphostin b42
Description
AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, AG-490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, AG-490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that AG-490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by AG-490 leads to lower levels of p85 phosphorylation and p-13 kinase activation. AG-490 is an inhibitor of JAK3.
R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin R50 - Very toxic to aquatic organisms
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36 - Wear suitable protective clothing S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
Hazard Symbols:
Xi
Storage temperature :
-20°C
x
Alternative Distributors of [AG-490]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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