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R-848

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Formula: C17H22N4O2
CAS: 144875-48-9
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Identification

Structural Formula
R-848
CAS:
144875-48-9
EINECS:
Molecular Formula:
C17H22N4O2
MDL:
MFCD00937759
SMILES:
CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N
Synonym:
4-amino-2-(ethoxymethyl)-alpha ; 4-amino-2-(ethoxymethyl)-alpha,alpha-dimethyl-1h-imidazo[4,5-c]quinoline-1-ethanol ; resiquimod ; r 848 ; 1-[4-amino-2-(ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol ; alpha-dimethyl-1h-imidazo(4,5-c)quinoline-1-ethanol ; r848,resiquimod ; chebi:36706 ; resquimod


Description

R-848 is a low-molecular-weight immune response modifier. It is reported to possess anti-tumor and anti-viral properties. It has been shown to mimic pathogen associated molecular patterns, activating immune cells through TLR7 and TLR8 (Toll-like receptors 7 and 8). It can induce interferon-alpha sythesis as well as the synthesis of other cytokines in various cell types. Evidence suggests its efficacy again herpes simples virus (HSV) type 2 in vivo. It has been shown to up-regulate IFN-γ production and proliferation by memory CD4+ T cells. It has also been shown to mimic CD40-induced B cell activation. R-848 is an activator of TLR7 and TLR8.


Suppliers

Santa Cruz Biotechnology, Inc.
203231
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Prices & Availability




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Properties for R-848

Molecular Weight:
314.3822 g·mol−1
Density:
1.28 g/cm3
Melting point:
166° C
Boiling point:
553.6°C at 760 mmHg
Flash point:
288.6°C
Solubility:
Soluble in DMSO (100 mM), ethanol (50 mM), 100% or 5% methanol, and dichloromethane. Insoluble in water.
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Storage temperature :
?20 °C
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Alternative Distributors of [R-848]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Haohua Industry Co., Ltd.

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