PD 166285 | CAS 212391-63-4 | Chemical-Suppliers

Element: 166285

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C-S » Chemicals » -PX73547

Identification

PD 166285

CAS:

212391-63-4

EINECS:

Molecular Formula:

C₂₆H₂₉Cl₄N₅O₂

MDL:

MFCD18086890

SMILES:

CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl

Synonym:

6-(2,6-dichloro-phenyl)-2-[4-(2-diethylamino-ethoxy)-phenylamino]-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one hydrochloride ; pd 166285 ; 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one hydrochloride ; pd 166285 dihydrochloride ; 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one ; 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-onedihydrochloride

Description

PD 166285 is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC₅₀ values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. PD 166285 is an RTK inhibitor with broad-spectrum properties and displays anti-angiogenic activity and anti-tumor efficacy when used with PDT (photodynamic therapy). PD 166285 is an inhibitor of EGFR.

Suppliers

Aea.ltd

A63126

Amadis Chemical Company Limited

ACCL2791395

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

208153

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CAS equal suppliers

PD166285

Excenen Pharmatech Co., Ltd.

EX-A1369

6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride

Hefei Hirisun Pharmatech Co., Ltd

HR130767

Prices & Availability

Data is processed

Properties for PD 166285

Molecular Weight:

585.35 g·mol−1

Melting point:

239-242 °C C

Solubility:

Soluble in water, methanol, and DMSO (100 mM).

Safety & Transport Information

Storage temperature :

Desiccate at RT

Alternative Distributors of [PD 166285]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | ShangHai Biochempartner Co., Ltd.

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MSDS:

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