CI 988 | CAS 130332-27-3 | Chemical-Suppliers

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C-S » Chemicals » -PX76535

Identification

CI 988

CAS:

130332-27-3

EINECS:

Molecular Formula:

C₃₅H₄₂N₄O₆

MDL:

SMILES:

CC(CC1=CNC2=CC=CC=C21)(C(=O)NCC(C3=CC=CC=C3)NC(=O)CCC(=O)O)NC(=O)OC4C5CC6CC(C5)CC4C6

Synonym:

4-[[(1r)-2-[[(2r)-3-(1h-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid ; [r-(r*,r*)]-4-[[2-[[3-(1h-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-

Description

CI-988 is a selective and effective antagonist of CCK-BR (CCK2; CCK-B; cholecystokinin 2) receptors. CCK is a neuroendocrine peptide described to play an important role in cell growth, cell proliferation, and other biological functions. Lung cancer cell studies report that Cl 988 inhibits the proliferation of NCI-H209 cells in vitro and the binding of CCK-8 to NCI-H209 cells. In addition Cl 988 blocks the elevated levels of cytosolic Ca²⁺ induced by CCK-8. Other CCK-BR inhibitors include L-365,260.

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Santa Cruz Biotechnology, Inc.

205244

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Properties for CI 988

Molecular Weight:

614.739 g·mol−1

Solubility:

Soluble in 100 mM DMSO

Safety & Transport Information

Storage temperature :

Store at +4 °C

Alternative Distributors of [CI 988]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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Mol File:

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MSDS:

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