K252c | CAS 85753-43-1 | Chemical-Suppliers

Element: k252c

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C-S » Chemicals » -PX79987

Identification

K252c

CAS:

85753-43-1

EINECS:

Molecular Formula:

C₂₀H₁₃N₃O

MDL:

MFCD00236435

SMILES:

C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5

Synonym:

staurosporine aglycone ; k-252c(staurosporinone) ; staurosporine aglycone >99% ; staurosporinone, k-252c ; 6,7,12,13-tetrahydro-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one ; staurosporinone, staurosporine aglycone ; staurosporonine ; k252c, ready made solution ; staurosporinone ; k-252c

Description

K252c is an aglycone, indolocarbazole alkaloid which is a protein kinase inhibitor of the Staurosporine family. K252c is a cell-permeable inhibitor of PKC (protein kinase C) (IC₅₀ = 2.45 μM) that displays approximately 10-fold selectivity over PKA (protein kinase A) (IC₅₀ = 25.7 μM). K252c is cytotoxic for A549 and P388 cells (IC₅₀ = 2-3 mM). K252c also inhibits LACTB (β-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B) and chymotrypsin (IC₅₀ values are 8, 8 and 10 μM respectively). K252c displays antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC₅₀ values range from 0.13-0.32 μM).

Suppliers

Santa Cruz Biotechnology, Inc.

24011

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CAS equal suppliers

K-252c

Iris Biotech GmbH

LS-1085

6,7,12,13-tetrahydro-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

Hefei Hirisun Pharmatech Co., Ltd

HR012820

6,7,12,13-Tetrahydro-5H-indolo-[2,3-a]pyrrolo[3,4-c]carbazol-5-one

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC106431

Prices & Availability

Data is processed

Properties for K252c

Molecular Weight:

311.34 g·mol−1

Density:

1.53 g/cm³ (Predicted)

Melting point:

251.24° C (Predicted)

Boiling point:

778.96° C at 760 mmHg (Predicted)

Solubility:

DMSO: 10 mg/mL, soluble

Safety & Transport Information

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes

Storage temperature :

-20°C

Alternative Distributors of [K252c]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences

Downloads

Mol File:

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MSDS:

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