L189 | CAS 64232-83-3 | Chemical-Suppliers

Element: l189

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C-S » Chemicals » -PX8219

Identification

L189

CAS:

64232-83-3

EINECS:

Molecular Formula:

C₁₁H₁₀N₄OS

MDL:

SMILES:

C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N

Synonym:

4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-

Description

L189 is a DNA ligase I, III and IV inhibitor (IC₅₀ values are 5, 9 and 5 μM respectively) that blocks DNA binding (K_i = 5 μM for DNA ligase I). Shown to preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ).

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Aea.ltd

A2856

Santa Cruz Biotechnology, Inc.

295349

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CAS equal suppliers

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

Finipharma Ltd

F856817136

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

Pharmacore Co., Limited

PL1407642228

Prices & Availability

Data is processed

Properties for L189

Molecular Weight:

246.29 g·mol−1

Solubility:

Soluble in DMSO (100 mM).

Safety & Transport Information

coming up soon

Alternative Distributors of [L189]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

Downloads

Mol File:

-/-

MSDS:

-/-