MK-0752 | CAS 471905-41-6 | Chemical-Suppliers

Element: 0752

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C-S » Chemicals » -PX86800

Identification

MK-0752

CAS:

471905-41-6

EINECS:

Molecular Formula:

C_₂₁H_₂₁ClF_₂O_₄S

MDL:

MFCD21608529

SMILES:

C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

Synonym:

MK-0752

Description

MK-0752 is known to be a moderately potent inhibitor of γ-secretase, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation in vitro.

Suppliers

Aea.ltd

A4998

Leap Chem Co., Ltd

LC126378

Santa Cruz Biotechnology, Inc.

364534

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CAS equal suppliers

3-((1r,4s)-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC106770

Prices & Availability

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Properties for MK-0752

Molecular Weight:

442.90 g·mol−1

Solubility:

≥89 mg/mL in DMSO <1 mg/mL in Water ≥45 mg/mL in Ethanol

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Alternative Distributors of [MK-0752]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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