Adapalene | CAS 106685-40-9 | Chemical-Suppliers

Element: adapalene

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C-S » Chemicals » adapalene-PX71735

Identification

Adapalene

CAS:

106685-40-9

EINECS:

Molecular Formula:

C₂₈H₂₈O₃

MDL:

MFCD03106112

SMILES:

COC1=C(C=C(C=C1)C1=CC2=C(C=C1)C=C(C=C2)C(O)=O)C12CC3CC(CC(C3)C1)C2

Synonym:

cd-271 ; p75(ntr) ; adapalene ; differin ; adapalene, >=99% ; differi ; adapalen ; adapalene-d6 ; adpl ; adapalene (200 mg)

Description

Adapalene is a retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.

Suppliers

Shandong Ench Chemical Co.,Ltd

SECC2701350

H&Z Industry Co.,Ltd

HIC180720

Ambeed, Inc.

A105293

Aozeal Certified Standards (AOCS), Inc.

A0004.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

EXCELLA GmbH

E108216

Jai Radhe Sales

JRS135540

Alfa (A Johnson Matthey Company)

A288864

Shanghai Worldyang Chemical Co., Ltd.

SWC3331332

Xiamen Equation Chemical Co.,Ltd

XECC2881440

Hangzhou Zhongqi Chem Co., Ltd

HZC2701080

Hainan Zhongxin Chemical Co., Ltd.

HZC3061224

Aecochem Corp.

AC126378

CSNpharm, Inc.

CSN12480

Hangzhou Keying Chem Co., Ltd.

HKC2701080

Sigma-Aldrich International GmbH

SI288864

scienTEST - bioKEMIX GmbH

S-B225900

Finetech Industry Limited

FIL225900

Carbone Scientific Co., Ltd.

CS252756

CM Fine Chemicals

CFC153612

AK Scientific, Inc.

AS171513

Xingrui Industry Co., Limited

XIL2611044

BOC Sciences

BS108324

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

203803

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CAS equal suppliers

Adapalene d3

Salsbury Chemicals, Inc.

SC5761728

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Wanko Chemical Co., Ltd.

WC1188035640

6-[3-(1-Adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid

BLD Pharmatech Ltd

BP936028080

Adapalene (6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid, 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid, CD-271, Differin)

United States Biological

A0859-80

Prices & Availability

Data is processed

Properties for Adapalene

Molecular Weight:

412.52 g·mol−1

Density:

~1.2 g/cm³ (Predicted)

Melting point:

319-3220C

Boiling point:

~606.3° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (>10 mg/ml), water (< 1 mg/ml at 25° C), ethanol (< 1 mg/ml at 25° C), and DMF (~5 mg/ml).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Storage temperature :

Store at +4 °C

Alternative Distributors of [Adapalene]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified