Identification
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2
Molecular Formula:
C3 4 H2 9 N7 O
SMILES:
O=C1NC2=C(C=CC=C2)N1C1CCN(CC2=CC=C(C=C2)C2=C(N=C3C=C4N=CNC4=CC3=N2)C2=CC=CC=C2)CC1
Synonym:
akt inhibitor viii, isozyme-selective, akti-1/2 ; akt inhibitor viii, isozyme-selective ; 1-(1-(4-(6-phenyl-1h-imidazo[4,5-g]quinoxalin-7-yl)benzyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one ; 1,3-dihydro-1-[1-[[4-(6-phenyl-1h-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2h-benzimidazol-2-one ; 2h-benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1h-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]- ; 1,3-dihydro-1-[1-[[4-(6-phenyl-1h-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2h-benzimidazol-2-one ; 1,3-dihydro-1-[1-[[4-(6-phenyl-1h-imidazo[4,5-γ],guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2h-benzimidazol-2-one ; 1-(1-(4-(6-phenyl-1h-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1h-benzo[d]imidazol-2( ; akt inhibitor viii (akti-1/2) ; 1,3-dihydro-1-[1-[[4-(6-phenyl-1h-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2h-benzimidazol-2-on
Description
Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. Akt Inhibitor VIII prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice.
Suppliers
Santa Cruz Biotechnology, Inc.
202048
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ShangHai Biochempartner Co., Ltd.
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Excenen Pharmatech Co., Ltd.
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AKT inhibitor VIII
Pharmacore Co., Limited
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Ambeed, Inc.
A314665
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Aea.ltd
A378756
1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC100722
Akti-1/2 (1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one)
United States Biological
A1123
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Properties
Safety & Transport
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Properties for Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2
Molecular Weight:
551.64 g·mol−1
Density:
~1.4 g/cm3 (Predicted)
Melting point:
242-245 °C (dec.)
Solubility:
Soluble in DMSO (5 mg/ml), and methanol.
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Safety & Transport Information
Storage temperature :
Refrigerator
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Alternative Distributors of [Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2]
Producers or manufacturers change the product range from time to time.
Currently there are no other manufacturers known.
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