Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond. Furthermore Dmb and Tmb amino acids prevent aggregation during solid phase synthesis and can prevent aspartimide formation when it is introduced before an Asp residue. They can also increase peptide cyclization efficiency. Standard coupling protocols can be applied with reagents such as PyBOP, DIC/HOBt or HATU. Acidic deprotection methods used with Wang resin generate the native sequence. References: Johnson, T. et al. J. Peptide Sci. 1995; 1: 11. Clausen, N. et al. in 'Peptide: Chemistry, Structure and Biology', Kaumaya, P.T.P. and Hodges, R.S. (Eds.), Mayflower Scientific Ltd., 1995; 71. Jauch, K. et al. in 'Peptide 1996: Proceeding of the 24th EPS', Ramage, R. and Epton, R. (Eds.), Mayflower Scientific Ltd., 1996; 497. El Haddadi, M. et al. J. Peptide Sci. 2000; 6: 560. Zahariev, S. et al. J. Peptide Sci. 2005; 11: 17.
Properties for N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-alpha-(2,4,6-trimethoxybenzyl)-glycine
Molecular Weight:
477.50578 g·mol−1
Physical Description:
colorless white powder
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Safety & Transport Information
Risk Codes:
R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T
Storage temperature :
2-8 °C
RID/ADR certification :
UN 2811 6.1 / PGIII
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