Amifostine | CAS 20537-88-6 | Chemical-Suppliers

Element: amifostine

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C-S » Chemicals » amifostine-PX63451

Identification

Amifostine

CAS:

20537-88-6

EINECS:

Molecular Formula:

C₅H₁₅N₂O₃PS

MDL:

MFCD00233058

SMILES:

C(CN)CNCCSP(=O)(O)O

Synonym:

ethyo ; wr2721c ; ym-08310 ; ethyol ; apaetp ; sapep ; au-95722 ; wr2721 ; ethiofos ; γphos

Description

Amifostine is a broad-spectrum radio- and chemoprotector. It restores transcriptional activity of specific p53 mutants, prevents chemotherapy-induced apoptosis and upregulates HIF-1α. Amifostine offers a selective protection to normal cells over tumor cells due to normal cells having a 275-fold greater concentration of alkaline phosphatase, by reducing renal toxicity, higher pH and better vascularity of the normal tissue. In physiological conditions, Amifostine is rapidly dephosporylated by alkaline phosphatase into an active free thiol. As a free thiol, Amifostine can act as a scavenger of free radicals against cytotoxic drugs. The compound has also displayed cytoprotectivity against alkylating drugs and cisplatin. Amifostine is an activator of p53.

Suppliers

Aozeal Certified Standards (AOCS), Inc.

A0129.00

Xiamen Equation Chemical Co.,Ltd

XECC3201600

Aecochem Corp.

AC140420

Hangzhou Lingrui Chemical Co., Ltd.

HLC3501400

Wanko Chemical Co., Ltd.

WC240720

scienTEST - bioKEMIX GmbH

S-B2501000

Finetech Industry Limited

FIL2501000

AK Scientific, Inc.

AS190570

Xingrui Industry Co., Limited

XIL2901160

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

200937

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CAS equal suppliers

Amifostine (2-[(3-Aminopropyl)-amino]ethanethiol Dihydrogen Phosphate, Phosphorothioic Acid S-[2-[(3-Aminopropyl)amino]ethyl]ester, Ethiofos, Gammaphos, SAPEP, CSC-296961, Ethyol)

United States Biological

A1372-52

Prices & Availability

Data is processed

Properties for Amifostine

Molecular Weight:

214.22 g·mol−1

Density:

1.37 g/cm³ (Predicted)

Melting point:

160-1610C

Boiling point:

441.70° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (1000 mg/ml).

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

Xn, Xi

Storage temperature :

2-8°C

Alternative Distributors of [Amifostine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

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MSDS:

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Amifostine 3H2O

Amifostine Trihydrate

Amifostine hydrate

Amifostine Thiol Dihydrochloride

Amifostine (2-[(3-Aminopropyl)-amino]ethanethiol Dihydrogen Phosphate, Phosphorothioic Acid S-[2-[(3-Aminopropyl)amino]ethyl]ester, Ethiofos, Gammaphos, SAPEP, CSC-296961, Ethyol)