APHS | CAS 209125-28-0 | Chemical-Suppliers

Element: aphs

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C-S » Chemicals » aphs-PX76948

Identification

APHS

CAS:

209125-28-0

EINECS:

Molecular Formula:

C₁₅H₁₈ O₂ S

MDL:

SMILES:

CCCCC#CCSC1=CC=CC=C1OC(=O)C

Synonym:

Phenol,2-(2-heptynylthio)-, acetate (9CI) ; APHS ; Phenol,2-(2-heptyn-1-ylthio)-, 1-acetate

Description

APHS is a selective inhibitor of Cox-2 (cyclooxygenase-2) that covalently modifies the enzyme by Ser⁵³⁰ acetylation. APHS is described to be 60 times as reactive and 100 times as selective for Cox-2 as compared to aspirin. APHS is demonstrated to block HIV-1 replication and indicated to operate through interaction with the reverse transcription process of HIV-1 proliferation. APHS is an inhibitor of Cox-1.

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Santa Cruz Biotechnology, Inc.

200668

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Properties for APHS

Molecular Weight:

264.38 g·mol−1

Density:

1.1 g/cm3

Melting point:

123.72° C

Boiling point:

363.3°C at 760 mmHg

Flash point:

165.7°C

Solubility:

Soluble in DMSO (5 mg/ml), and ethanol (8 mg/ml).

Safety & Transport Information

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Alternative Distributors of [APHS]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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Mol File:

-/-

MSDS:

-/-