ARC 239 dihydrochloride | CAS 67339-62-2

Element: dihydrochloride

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Identification

ARC 239 dihydrochloride

CAS:

67339-62-2

EINECS:

Molecular Formula:

C₂₄H₃₁Cl₂N₃O₃

MDL:

MFCD16875414

SMILES:

CC1(C2=CC=CC=C2C(=O)N(C1=O)CCN3CCN(CC3)C4=CC=CC=C4OC)C.Cl.Cl.O

Synonym:

2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-4,4-dimethyl-1,3-(2h,4h)-isoquinolindionedihydrochloride ; ar-c239 ; 2-[2-[4-(2-methoxyphenyl)piperazino]ethyl]-4,4-dimethylisoquinoline-1,3(2h,4h)-dione ; 1,3(2h,4h)-isoquinolinedione,2-[2-[4-(2- methoxyphenyl)-1-piperazinyl]ethyl]-4,4- dimethyl- ; 2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-4,4-dimethyl-1,3(2h,4h)-isoquinolinedione ; (2-[2-[4-(o-methoxyphenyl)piperazin-1-yl]ethyl]-4,4-dimethyl-1,3-(2h,4h)-isoquinolinedione dihydrochloride hydrate ; arc 239 dihydrochloride ; arc2392hcl ; arc 239 dihydrochloride hydrate ; 2-[2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2h,4h)-isoquinolindione dihydrochloride

Description

ARC 239 dihydrochloride hydrate is a selective α2B-AR adrenoceptor antagonist with a pK_D value of 8.8. This antagonist is known to display inhibitory effects on α2A-AR (α2A) and α2D receptors with pK_D values of 6.7 and 6.4 respectively. Studies indicate that ARC 239 dihydrochloride is 100-fold more selective towards the α2B-AR (α2B adrenoceptor) than chlorpromazine and 7-hydroxychlorpromazine. Studies conducted on pentobarbital-treated dogs and rats show that ARC 239 dihydrochloride competitively antagonizes pressor responses to adrenaline, while inhibiting these pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium. ARC 239 dihydrochloride hydrate is an inhibitor of α2B-AR.

Suppliers

Santa Cruz Biotechnology, Inc.

203518

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CAS equal suppliers

ARC 239 dihydrochloride hydrate

Santa Cruz Biotechnology, Inc.

sc-203518

ARC 239 dihydrochloride hydrate

ShangHai Biochempartner Co., Ltd.

BCP14554

2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride

Amadis Chemical Company Limited

ACCL45136225680

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Properties for ARC 239 dihydrochloride

Molecular Weight:

407.5054 g·mol−1

Density:

1.167 g/cm3

Boiling point:

595.8°C at 760 mmHg

Flash point:

314.1°C

Solubility:

Soluble in DMSO (100 mM), and water (100 mM).

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Codes:

S60 - This material and its container must be disposed of as hazardous waste
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Symbols:

Xn, N