6β-Prostaglandin I1 | CAS 62770-50-7

Element: prostaglandin beta

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C-S » Chemicals » beta-prostaglandin-PX65874

Identification

6β-Prostaglandin I1

CAS:

62770-50-7

EINECS:

Molecular Formula:

C₂₀H₃₄O₅

MDL:

SMILES:

CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O

Synonym:

6s,9alpha-epoxy-11alpha,15s-dihydroxy-prost-13e-en-1-oic acid ; 5,6-dihydroprostaglandin i2 ; 5,6-dihydroprostacyclin ; 6beta-prostaglandin i1 ; (6s,13e,15s)-6,9α-epoxy-11α,15-dihydroxyprost-13-en-1-oic acid ; 5,6beta-dihydro pgi2

Description

6β-Prostaglandin I1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. The compound has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.