Albizziin acts as a competitive inhibitor of asparagine synthetase with respect to glutamine in mammalian cells. It acts also as an inhibitor of glutamate synthase in ectomycorrhizal fungal isolates and inhibitor of glutamine metabolism in microbes. Andrulis I.L., Evans-Blackler S., Siminovitch L., Characterization of single step albizziin-resistant Chinese hamster ovary cell lines with elevated levels of asparagine synthetase activity. J. Biol. Chem. 1985, 260, 7523-7. Dura M.A., Flores M., Toldra F., Purification and characterisation of a glutaminase from Debaryomyces spp. Int. J. Food Microbiol. 2002, 76, 117-26. Schroeder D.D., Allison A.J., Buchanan J.M., Biosynthesis of the purines. XXXII. Effect of albizziin and other reagents on the activity of formylglycinamide ribonucleotide amidotransferase. J. Biol. Chem. 1969, 244, 5856-65.
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