BRL-50481 | CAS 433695-36-4 | Chemical-Suppliers

Element: 50481

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C-S » Chemicals » brl-PX79871

Identification

BRL-50481

CAS:

433695-36-4

EINECS:

Molecular Formula:

C₉H₁₂N₂O₄S

MDL:

MFCD03039912

SMILES:

CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C

Synonym:

Description

BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.

Suppliers

Amadis Chemical Company Limited

ACCL2791395

Santa Cruz Biotechnology, Inc.

201178

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CAS equal suppliers

BRL50481

CSNpharm, Inc.

CSN21529

N,N,2-Trimethyl-5-nitrobenzenesulfonamide

TCI Chemicals (India) Pvt. Ltd.

T3112

N,N,2-Trimethyl-5-nitrobenzenesulfonamide

Leap Chem Co., Ltd

LC29528856

Prices & Availability

Data is processed

Properties for BRL-50481

Molecular Weight:

244.27 g·mol−1

Density:

~1.3 g/cm³ (Predicted)

Melting point:

141.24° C (Predicted)

Boiling point:

~391.1° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (>40 mg/mL), and ethanol (5 mg/mL). Insoluble in water.

Safety & Transport Information

coming up soon

Alternative Distributors of [BRL-50481]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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MSDS:

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