Capsazepine | CAS 138977-28-3 | Chemical-Suppliers

Element: capsazepine

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C-S » Chemicals » capsazepine-PX79461

Identification

Capsazepine

CAS:

138977-28-3

EINECS:

Molecular Formula:

C₁₉H₂₁ClN₂O₂S

MDL:

MFCD00153778

SMILES:

C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O

Synonym:

capsazepine,98% ; n-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2h-2-benzazepine-2-carbothioamide ; capsazepine synthetic analog of c ; capsazepine ; 2-[[2-(4-chlorophenyl)ethylamino]thiocarbonyl]-2,3,4,5-tetrahydro-1h-2-benzazepine-7,8-diol ; n-[2-(chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2h-2-benzazepine-2-carbothioamide

Description

Capsazepine is a competitive antagonist of the VR1 (TRPV1, also transient receptor potential vanilloid type 1), antagonizing the effects produced by Capsaicin at this receptor. The VR1 (TRPV1 receptor) is a non-selective ligand-gated cation channel that responds to noxious heat, protons, and Capsaicin, producing nociception signals. Capsazepine also activates ENaCδ (amiloride-sensitive epithelial Na⁺ channel). Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.

Suppliers

Aea.ltd

A77154

Ambeed, Inc.

A231605

Shandong Ench Chemical Co.,Ltd

SECC3301650

A.G. Scientific

AS165495

CSNpharm, Inc.

CSN10542

Xingrui Industry Co., Limited

XIL3191276

Amadis Chemical Company Limited

ACCL3411705

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

201098

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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Prices & Availability

Data is processed

Properties for Capsazepine

Molecular Weight:

376.9 g·mol−1

Density:

1.35 g/cm³ (Predicted)

Melting point:

155-157 °C

Boiling point:

581.13° C at 760 mmHg (Predicted)

Solubility:

methanol: soluble

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Classes:

6.1(a)

Hazard Symbols:

Storage temperature :

2-8°C

RID/ADR certification :

2811

Alternative Distributors of [Capsazepine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

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MSDS:

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Capsazepine (N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide)