Carvedilol | CAS 72956-09-3 | Chemical-Suppliers

Element: carvedilol

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C-S » Chemicals » carvedilol-PX77294

Identification

Carvedilol

CAS:

72956-09-3

EINECS:

Molecular Formula:

C₂₄H₂₆N₂O₄

MDL:

MFCD00864692

SMILES:

COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O

Synonym:

carca ; artist ; cadilan ; kredex ; coreg ; dq-2466 ; artione ; carloc ; querto ; carvas

Description

Carvedilol is a AR (α₁ and β-adrenergic receptor) antagonist with antioxidant properties. Studies show that the receptors α₁D-AR and α₁B-AR have a greater affinity for Carvedilol in comparison to the receptor β₁-AR subtype. Carvedilol has been observed to block the oscillatory intracellular calcium changes induced by α₁D-AR and α₁B-AR, and shown to have a higher oxidative effect than Atenolol. The S(-) enantiomer of Carvedilol acts as a β-blocker, and the R(+) and S (-) enantionmers both block the α₁. Carvedilol is an inhibitor of α₁B-AR, β₁-AR, β₂-AR and α₁D-AR.

Suppliers

Aozeal Certified Standards (AOCS), Inc.

C0002.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

H&Z Industry Co.,Ltd

HIC200800

Shandong SanYoung Industry Co., Ltd

SSI3501400

Arevipharma GmbH

A160320

Inke S.A.

IS90270

Jai Radhe Sales

JRS150600

CellMark AB

CA110330

Xiamen Equation Chemical Co.,Ltd

XECC3201600

Sancai Industry Co.,Ltd.

SIC240960

Aecochem Corp.

AC140420

Sigma-Aldrich International GmbH

SI320960

scienTEST - bioKEMIX GmbH

S-B2501000

AK Scientific, Inc.

AS190570

Capot Chemical Co., Ltd.

18218

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

200157

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CAS equal suppliers

Carvedilol

Jiwan Pharmaceutical Technology Co., Ltd.

JPT4921968

Prices & Availability

Data is processed

Properties for Carvedilol

Molecular Weight:

406.47 g·mol−1

Density:

1.25 g/cm³ (Predicted)

Melting point:

113-117 °C

Boiling point:

655.22° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), methanol (33.8 mg/ml), phosphate buffer (pH 4) (0.43 mg/ml) at 37° C, water (partly miscible), chloroform, methylene chloride, and ethyl ether (slightly soluble). Insoluble in isopropanol.

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Classes:

irritant

Hazard Symbols:

N, Xn

Storage temperature :

Store at +4 °C

RID/ADR certification :

UN 3077 9 / PG 3

Alternative Distributors of [Carvedilol]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified