Caspase-1 Inhibitor II | CAS 178603-78-6

Element: inhibitor caspase

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C-S » Chemicals » caspase-inhibitor-PX67390

Identification

Caspase-1 Inhibitor II

CAS:

178603-78-6

EINECS:

Molecular Formula:

C₂₄H₃₃ClN₄O₈

MDL:

MFCD00237124

SMILES:

C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CCl)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)C

Synonym:

ac-tyr-val-ala-asp-cmk ; ac-yvad-cmk ; ac-tyr-val-ala-asp-chloromethylketone ; ice inhibitor ii ; n-ac-tyr-val-ala-asp-cmk ; ac-tyr-val-ala-asp-ch2cl ; ac-tyr-ala-asp-chloromethylketone ; caspase-1 inhibitor ii ; il-1beta converting enzyme inhibitor ii ; ac-yvad-chloromethylketone

Description

Caspase-1 Inhibitor II (Ac-YVAD-CMK) is a cell-permeable and irreversible inhibitor of caspase-1 (K_i = 760 pM), caspase-4, and caspase-5. It also inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)₂ tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.
Additional caspase-1 inhibitors available:
caspase-1 inhibitor
caspase-1 inhibitor VI
Caspase-1 Inhibitor IV (sc-300324)
Caspase-1 Inhibitor I (sc-358878)