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2-Chloro-2′-deoxyadenosine

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Formula: C10H12ClN5O3
CAS: 4291-63-8
search Element: deoxyadenosine chloro prime
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Identification

Structural Formula
2-Chloro-2′-deoxyadenosine
CAS:
4291-63-8
EINECS:
Molecular Formula:
C10H12ClN5O3
MDL:
MFCD00153939
SMILES:
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(N=C3N)Cl)CO)O
Synonym:
leustatin ; rwj26251 ; jk 6251 ; 2-cl-dado ; 2-cl-da ; 2cda ; cldado ; leustat ; cda ; leustati


Description

2-Chloro-2'-deoxyadenosine is a deoxyadenosine analog that induces apoptosis in chronic lymphocytic leukemia (CLL) cells. Studies show that 2-chloro-2′-deoxyadenosine can be produced from intact cells of Escherichia coli that produce B-2194 thermostable purine-nucleoside phosphorylase II. In addition, in vitro studies show that 2-Chloro-2′-deoxyadenosine can inhibit human T and B cell lymphoproliferative responses possibly by inhibiting DNA repair. Furthermore, Staphylococcus aureus Cowan-induced expression of CD25 on B-cells is suppressed by 2-Chloro-2′-deoxyadenosine. 2-Chloro-2′-deoxyadenosine is an inhibitor of Adenosine deaminase.


Suppliers

Santa Cruz Biotechnology, Inc.
202399
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Prices & Availability




Data is processed


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Properties for 2-Chloro-2′-deoxyadenosine

Molecular Weight:
285.69 g·mol−1
Density:
2.04 g/cm3 (Predicted)
Melting point:
181-185 °C(lit.)
Boiling point:
597.58° C at 760 mmHg (Predicted)
Solubility:
Methanol, Water
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Safety & Transport Information

Risk Codes:
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T
Hazard symbol T
Storage temperature :
2-8°C
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Alternative Distributors of [2-Chloro-2′-deoxyadenosine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Farmachem SA Machineries & Marketing | Nantong Chem-Tech. (Group) Co., Ltd. | Beijing Ribio Biotech Co., Ltd. | Toptechlab Pharmaceutical Co., Ltd. | Originchem Co., Ltd. | New Dragon Industrial Co., Ltd | Zhejiang Esun Chemical Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Benro Internatinal Co., Linc | Taizhou Bolon Pharmachem Co.,Ltd.. / Bolon Pharm & Chem Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | SYNCHEM OHG | Shanghai Richem International Co., Ltd. | Hangzhou Think Chemical Co., Ltd. | Ark Pharm, Inc. | Shanghai Marketing Center of Yangzhou Princechem Co., Ltd. | Lanospharma Laboratories Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | Jinan Great Chemical Co., Ltd. | Hangzhou Holypharm Biotech Co., Ltd. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Hefei Photochem Trading Co., Ltd | Watson International Ltd | BOC Sciences | Jinan Haohua Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Wanko Chemical Co., Ltd. | Haihang Industry Co., Ltd.

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