5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid | CAS 916046-55-4

Element: fluorophenyl pyrrolidine acetic chloro indole methyl trioxo spiro acid

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C-S » Chemicals » chloro-fluorophenyl-methyl-trioxo-spiro-indole-pyrrolidine-acetic-acid-PX67752

Identification

5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid

CAS:

916046-55-4

EINECS:

Molecular Formula:

C₂₀H₁₄ClFN₂O₅

MDL:

SMILES:

C1C(=O)N(C(=O)C12C3=C(C=CC(=C3)Cl)N(C2=O)CC(=O)O)CC4=CC=CC=C4F

Synonym:

Description

5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid is a potent CRTH2/DP2 receptor antagonist (K_i = 37 nM). The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on eosinophils, basophils and Th2 cells where it mediates the chemotactic activity of PGD2.

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Santa Cruz Biotechnology, Inc.

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Properties for 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid

Molecular Weight:

416.8 g·mol−1

Safety & Transport Information

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Alternative Distributors of [5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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