13-cis-Retinoic acid | CAS 4759-48-2

Element: retinoic acid

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C-S » Chemicals » cis-retinoic-acid-PX68531

Identification

13-cis-Retinoic acid

CAS:

4759-48-2

EINECS:

225-296-0

Molecular Formula:

C₂₀H₂₈O₂

MDL:

MFCD00079542

SMILES:

CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=CC(=O)O)/C)/C

Synonym:

isotrex ; 13-cis-ra ; retinoin ; 13-ra ; accutane ; ro-4-3780 ; roaccutane ; roaccutan ; ro4-3780 ; teriosal

Description

13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. Clinically, 13-cis-Retinoic acid is primarily used in the treatment of severe recalcitrant nodular acne. Its effects include reducing the production of sebum, shrinking the size of the sebaceous glands, stabilizing keratinization, preventing comedones from forming, and reducing inflammation of inflammatory acne. Though the exact mechanism of action of 13-cis-Retinoic acid is not fully understood, studies have suggested that the compound alters DNA transcription and induces apoptosis in select types of cells throughout the body.

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Prices & Availability

Data is processed

Properties for 13-cis-Retinoic acid

Molecular Weight:

300.44 g·mol−1

Density:

1.01 g/cm³ (Predicted)

Melting point:

172-175 °C(lit.)

Boiling point:

~462.80° C at 760 mmHg (Predicted)

Solubility:

Soluble in chloroform (50 mg/ml), DMSO (60 mg/ml at 25° C), water (<1 mg/ml at 25° C), ethanol (25 mg/ml), and ether (sparingly).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R61 - May cause harm to the unborn child

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use

Hazard Symbols:

Storage temperature :

-20°C

Alternative Distributors of [13-cis-Retinoic acid]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Jinan Haohua Industry Co., Ltd. | Haihang Industry Co., Ltd.