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Diclofenac Sodium

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Formula: C14H10Cl2NNaO2
CAS: 15307-79-6
search Element: diclofenac sodium
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Identification

Structural Formula
Diclofenac Sodium
CAS:
15307-79-6
EINECS:
239-346-4
Molecular Formula:
C14H10Cl2NNaO2
MDL:
MFCD00082251
SMILES:
C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]
Synonym:
ortofen ; kriplex ; diacron ; valetan ; gp45840 ; kroplex ; voldal ; benfofen ; naclof ; ecofenac


Description

Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac. Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4'-hydroxy diclofenac which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.


Suppliers

Aozeal Certified Standards (AOCS), Inc.
D0001.00
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI23469384
+
Shandong Minglang Chemical Co., Ltd
SMC11904760
+
Lori Industry Co., Ltd
LI7482244
+
H&Z Industry Co.,Ltd
HIC6802720
+
Unilong Industry Co.,Ltd
UIC8163264
+
Ambeed, Inc.
A105695
+
Krada CPS Industry S.L
KCIS7483740
+
Shandong SanYoung Industry Co., Ltd
SSI11904760
+
European Manufacturers Assoc. Inc.
EMA11564624
Pharma Greven GmbH
PG6121836
Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT17348670
+
B.M.P. Bulk Medicines & Pharmaceuticals GmbH
BBMP14967480
+
AXO Industry SA
AIS5102040
+
Caesar & Loretz GmbH
CL6802040
+
Xiamen Equation Chemical Co.,Ltd
XECC10885440
+
Sancai Industry Co.,Ltd.
SIC8163264
+
Hainan Zhongxin Chemical Co., Ltd.
HZC11564624
+
Aecochem Corp.
AC4761428
+
CSNpharm, Inc.
CSN16174
Hangzhou Keying Chem Co., Ltd.
HKC10204080
+
Hangzhou Lingrui Chemical Co., Ltd.
HLC11904760
+
Carbone Scientific Co., Ltd.
CS9522856
+
AK Scientific, Inc.
AS6461938
+
Xingrui Industry Co., Limited
XIL9863944
+
Zehao Industry Co., Ltd.
ZI8162448
+
Leap Chem Co., Ltd
LC6121836
+
Santa Cruz Biotechnology, Inc.
202136
Dayang Chem (Hangzhou) Co.,Ltd.
DC10544216
+
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Prices & Availability




Data is processed


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Properties for Diclofenac Sodium

Molecular Weight:
318.13 g·mol−1
Density:
~0.63 g/cm3
Melting point:
288-290 °C
Solubility:
H2O: 50 mg/mL
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Hazard Statements

GHS06

GHS06
Toxic
  • Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

Risk Codes:
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(b)
Hazard Symbols:
T, Xi
Hazard symbol T Hazard symbol Xi
Storage temperature :
-20 °C Freezer
RID/ADR certification :
UN 2811 6.1 / PG 3
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Alternative Distributors of [Diclofenac Sodium]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Cheng Fong Chemical Co., Ltd. | Hallochem Pharma Co., Ltd. | 3B Scientific Corporation | Shanghai Eagle Chemical Co., Ltd. | Jiangsu Guotai International Group Co., Ltd. | Hwasun Pharmaceutical Co.Ltd. | Shanghai Chemicals & Pharmaceuticals Co., Limited | Pharmasi Chemicals Co., Ltd. | Ningbo Pangs Chem Int'l Co., Ltd. | Golden Harvest Fine Chemical Co., Ltd. | Changzhou An-Yuan Imp. & Exp. Corporation | Dimysh Trading Company | New Dragon Industrial Co., Ltd | Hana Pharm. Co., Ltd. | Zibo Panxin Pharmaceutical Co., Ltd. | Hangzhou Hysen Pharma Co., Ltd. | San Yueh Chemical Corp. | Jinan Great Chemical Co., Ltd. | Ningbo Hi-Tech Biochemicals Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | Hubei MaxSource Chem Co., Ltd. | Pharmfar Co., Ltd. | Watson International Ltd | Aopharm | Suzhou Bichal Biological Technology Co., Ltd. | BOC Sciences | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Sciyu Biotech Co., Ltd. | C-LAB Chemievermittlung GmbH | Jinan Haohua Industry Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Gihi Chemicals Co., Limited | DKSH International AG | Haihang Industry Co., Ltd.

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