H-89 Dihydrochloride | CAS 130964-39-5

Element: dihydrochloride

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C-S » Chemicals » dihydrochloride-PX2049554

Identification

H-89 Dihydrochloride

CAS:

130964-39-5

EINECS:

Molecular Formula:

C₂₀H₂₀BrN₃O₂S.2ClH.H₂O

MDL:

MFCD00214120

SMILES:

C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl

Synonym:

5-isoquinolinesulfonamide, n-[2-[[3-(4-bromophenyl)-2-propenyl]amino]ethyl]-, dihydrochloride ; n-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide hydrochloride ; (e)-n-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride ; h-89 hydrate dihydrochloride ; (e)-n-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride ; protein kinase inhibitor h-89 dihydrochloride ; h-89 dihydrochloride hydrate ; h-89 dihydrochloride hydrate,n-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride ; h 89 2hcl

Description

H-89, Dihydrochloride is a cell-permeable, non-selective, reversible, ATP-competitive, potent inhibitor of PKA (cyclic AMP-dependent protein kinase). PKA regulates glycogen, sugar and lipid metabolism and plays an important role in the cell cycle. H-89, once thought to be a selective PKA inhibitor, has been shown to also inhibit CaM kinase II, casein kinase I, Rsk-2 (MAPKAP-K1b), MSK1, MYLK (myosin light chain kinase), Akt1 (PKB α), PKC μ, Rock-2 (ROCK-II) and p70 S6 kinase α.

Suppliers

Aea.ltd

A280560

Finetech Industry Limited

FIL10004000

Zehao Industry Co., Ltd.

ZI9602880

Santa Cruz Biotechnology, Inc.

3537

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Prices & Availability

Data is processed

Properties for H-89 Dihydrochloride

Molecular Weight:

537.304 g·mol−1

Melting point:

195-200 °C

Safety & Transport Information

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes

Storage temperature :

2-8°C

Alternative Distributors of [H-89 Dihydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ShangHai Biochempartner Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Cfm Oskar Tropitzsch GmbH