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H-1152 Dihydrochloride

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Formula: C16H23Cl2N3O2S
CAS: 871543-07-6

Identification

Structural Formula
H-1152 Dihydrochloride
CAS:
871543-07-6
EINECS:
Molecular Formula:
C16H23Cl2N3O2S
MDL:
MFCD06411451
SMILES:
CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl
Synonym:


Description

H-1152 . dihydrochloride is a selective ATP-competitive inhibitor of rho-kinase (ROCK) inhibitor, cell permeable, highly specific, and potent (Ki = 1.6 nM). Exhibits weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27mM for PKC and 10.1 mM for MLCK) and is more potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid and inhibits EP3-stimulated NO formation. H-1152 . dihydrochloride prevents fragmentation of apoptotic cells. Relieves neuropathic pain.


Suppliers

Amadis Chemical Company Limited
ACCL13646820
Santa Cruz Biotechnology, Inc.
203592
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Properties for H-1152 Dihydrochloride

Molecular Weight:
392.34 g·mol−1
Melting point:
182-184°C
Solubility:
Soluble in water, ethanol (~20 mg/ml), DMSO (~12.5 mg/ml), DMF (~15 mg/ml), and methanol.
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Safety & Transport Information

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Alternative Distributors of [H-1152 Dihydrochloride]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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