H-7, Dihydrochloride | CAS 108930-17-2

Element: dihydrochloride

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C-S » Chemicals » dihydrochloride-PX78912

Identification

H-7, Dihydrochloride

CAS:

108930-17-2

EINECS:

Molecular Formula:

C₁₄H₁₇N₃O₂S.2ClH

MDL:

MFCD00036961

SMILES:

CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl

Synonym:

piperazine,1-(5-isoquinolinylsulfonyl)-2-methyl-, dihydrochloride (9ci) ; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride ; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine 2hcl ; 5-[(2-methyl-1-piperazinyl)sulfonyl]isoquinoline hydrochloride ; h-7 dihydrochloride ; 5-[(2-methylpiperazin-1-yl)sulfonyl]isoquinoline dihydrochloride ; 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine dihydrochloride ; h-7 ; 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2hcl ; h-7 dihydrochloride,98% ; (-)-1-(5-isoquinolinesulfonyl)-2-methylpiperazine, di-hcl salt ; isoquinoline,5-[(2-methyl-1-piperazinyl)sulfonyl]-,hydrochloride (1:2) ; (+/-)-1-(5-isoquinolinesulfonyl)-2-methylpiperazine 2hcl

Description

H-7, Dihydrochloride is a cell-permeable, reversible, ATP-competitive Ser/Thr kinase inhibitor. H-7 is a broad spectrum kinase inhibitor that has been shown to inhibit MYLK (MLCK) (K_i=97 µM), cAMP-dependent protein kinase (PKA) (K_i = 3.0 uM), Protein Kinase C (PKC) (K_i = 6.0 uM), and cGMP-dependent protein kinase (cGKI, PKG) (K_i = 5.8 uM). H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. This compound is shown to inhibit Topo I and II in murine L929 cells and induce apoptosis through PKC inhibition.