Y-27632 dihydrochloride | CAS 146986-50-7

Element: dihydrochloride 27632

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C-S » Chemicals » dihydrochloride-PX984

Identification

Y-27632 dihydrochloride

CAS:

146986-50-7

EINECS:

Molecular Formula:

C₁₄H₂₁N₃O.2HCl

MDL:

MFCD03490488

SMILES:

C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

Synonym:

Description

Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.

Suppliers

Ambeed, Inc.

A101744

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI317412696

H&Z Industry Co.,Ltd

HIC9203680

Aea.ltd

A322644

Finetech Industry Limited

FIL11504600

Hefei Hirisun Pharmatech Co., Ltd

HR060244

AK Scientific, Inc.

AS8742622

Xingrui Industry Co., Limited

XIL13345336

BOC Sciences

BS5521656

Amadis Chemical Company Limited

ACCL14267130

Leap Chem Co., Ltd

LC8282484

Santa Cruz Biotechnology, Inc.

281642

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CAS equal suppliers

Y-27632

ShangHai Biochempartner Co., Ltd.

BCP01863

Y-27632

Pharmacore Co., Limited

PL161483

Y-27632

Ambeed, Inc.

A112358

Y-27632

Excenen Pharmatech Co., Ltd.

EX-A423

Y-27632

CSNpharm, Inc.

CSN12226

Y-27632

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI4831932

Y-27632

Aea.ltd

A4998

Y-27632, free base

Santa Cruz Biotechnology, Inc.

3536

Cyclohexanecarboxamide, 4-[(1r)-1-aminoethyl]-n-4-pyridinyl-, trans-

Angene International Limited

AGN-PC-0O3F2M

Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-

CM Fine Chemicals

CFC924836992

Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-

Sirius Fine Chemicals SiChem GmbH

SC-0048

(+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride

Pt. Sarana Bela Nusa

PSBN1476073800

Prices & Availability

Data is processed

Properties for Y-27632 dihydrochloride

Molecular Weight:

338.28025 g·mol−1

Solubility:

Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [Y-27632 dihydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | Shanghai Sun-shine Chemical Technology Co., Ltd. | ChengDu KaiXin Technology Development Co., Ltd. | BOC Sciences | Jinan Haohua Industry Co., Ltd.