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16,16-dimethyl Prostaglandin E2 p-(p-acetamidobenzamido) phenyl ester

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Formula: C37H48N2O7
CAS: 62873-55-6

Identification

Structural Formula
16,16-dimethyl Prostaglandin E2 p-(p-acetamidobenzamido) phenyl ester
CAS:
62873-55-6
EINECS:
Molecular Formula:
C37H48N2O7
MDL:
SMILES:
CCCCC(C)​(C)​C(O)​C=C[C@H]​1C(O)​CC(=O)​C1C/C=CCCCC(=O)​Oc1ccc(cc1)​ N(C=O)​c1ccc(cc1)​NC(=O)​C
Synonym:
16,16-dimethyl prostaglandin e2 p-(p-acetamidobenzamido) phenyl ester ; 16,16-dimethyl pge2 4-(4-acetamidobenzamido) phenyl ester ; 9-oxo-11alpha,15r-dihydroxy-16,16-dimethyl-prosta-5z,13e-dien-1-oic acid, 4-(4-acetylaminobenzoylamino)phenyl ester ; 16,16-dimethylprostaglandin e2 (4-acetamidobenzamido)phenyl ester


Description

16,16-dimethyl Prostaglandin E2 p-(p-acetamidobenzamido) phenyl ester is a crystalline prostaglandin derivative believed to act as a prodrug for 16,16-dimethyl PGE2. 16,16-dimethyl PGE2 is an antisecretory, antiulcer Prostaglandin E2 (PGE2) analog with potent cytoprotective activity that binds to PGDH (prostaglandin dehydrogenase or HPGD), but is resistant to metabolism, thereby inhibiting the enzyme. This enhanced resistance to metabolism imparts a higher duration of activity than Prostaglandin E2, but the methylations do not severely affect the binding affinity for all four EP receptors (EP1,2,3, and 4).


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Properties for 16,16-dimethyl Prostaglandin E2 p-(p-acetamidobenzamido) phenyl ester

Molecular Weight:
632.79 g·mol−1
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Mol File:
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MSDS:
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