4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide | CAS 193551-00-7

Element: dimethylamino hydroxyamino benzamide oxohexyl

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C-S » Chemicals » dimethylamino-hydroxyamino-oxohexyl-benzamide-PX56460

Identification

4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide

CAS:

193551-00-7

EINECS:

Molecular Formula:

C₁₅H₂₃N₃O₃

MDL:

MFCD05863979

SMILES:

CN(C)C1=CC=C(C=C1)C(=O)NCCCCCC(=O)NO

Synonym:

Description

4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide is a selective histone deacetylase (HDAC1) inhibitor. It is very similar in structure to M 344, and has similar potency to trapoxin A and trapoxin B. Trichostatin A (sc-3511) is a more potent inhibitor of the HDAC enzyme, however this 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide compound has equivalent selectivity and is much more cost-effective for the inhibition of HDAC. The deacetylation of histones by HDAC is associated with transcriptional silencing.