DMNB | CAS 20357-25-9 | Chemical-Suppliers

Element: dmnb

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C-S » Chemicals » dmnb-PX68470

Identification

DMNB

CAS:

20357-25-9

EINECS:

243-762-1

Molecular Formula:

C₉H₉NO₅

MDL:

MFCD00007134

SMILES:

COC1=C(C=C(C(=C1)C=O)[N+](=O)[O-])OC

Synonym:

Description

DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-PK (IC₅₀ = 15 μM). DMNB is shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K56. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair.

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