Doxycycline Hyclate | CAS 24390-14-5

Element: doxycycline hyclate

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C-S » Chemicals » doxycycline-hyclate-PX64271

Identification

Doxycycline Hyclate

CAS:

24390-14-5

EINECS:

Molecular Formula:

C₂₂H₂₄N₂O₈.HCl

MDL:

MFCD07357237

SMILES:

CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=C(C(=O)[C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)C(=O)N)O)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=C(C(=O)[C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)C(=O)N)O)N(C)C)O.O.Cl.Cl

Synonym:

doxycycline hydrochlocide ; doxycycline hc1 ; doxycycline hyclate cos ; doxycycline hyclate usp ; doxycycline hyclate usp grade ; doxycycline hyclate ; doxycycline hyclate (200 mg) ; doxycycline hyclate, bp ; doxycycline api ; doxycycline hydrate

Description

Doxycycline hyclate, also called doxycycline is an antimicrobial tetracycline that acts as an inhibitor of a wide range of matrix metalloproteinases (MMPs). This product has been observed to significantly decrease the levels and activity of metalloproteinase-9 (MMP-9) in corneal erosion studies. Rheumatoid arthriitis studies indicate that doxycycline can block the degradation of type II collagen, and not type I collagen, as well as down regulate the expression levels and activity of MMP-8. Reports suggest that doxycycline blocks collagen activity and in smooth muscle studies increases smooth muscle cell adhesion, and changes the reorganization of fibrillar collagen matrices and cell migration. Additionally, doxycycline has been observed to alter the expression of apicoplast genes in plasmodium falciparum, and inhibit tissue formation. Doxycycline hyclate is an inhibitor of MMP-1 and MMP-8.

Suppliers

Ambeed, Inc.

A148893

Aozeal Certified Standards (AOCS), Inc.

D0024.00

Shandong Ench Chemical Co.,Ltd

SECC11405700

H&Z Industry Co.,Ltd

HIC7603040

XD BIOCHEMS Ltd

XB5701710

Nantong Xindao Biotech Ltd

NXB9883952

Zeta Pharmaceuticals Inc.

ZP9502850

Eastar Chemical Corporation

ECC10264104

Alpha Biopharmaceuticals Co., Ltd.

AB12923876

AXO Industry SA

AIS5702280

Alfa (A Johnson Matthey Company)

A12163648

X´ian Taicheng Chem Co., Ltd

XTC11024408

Sancai Industry Co.,Ltd.

SIC9123648

CSNpharm, Inc.

CSN15946

Sigma-Aldrich International GmbH

SI12163648

scienTEST - bioKEMIX GmbH

S-B9503800

Finetech Industry Limited

FIL9503800

AK Scientific, Inc.

AS7222166

Xingrui Industry Co., Limited

XIL11024408

BOC Sciences

BS4561368

Leap Chem Co., Ltd

LC6842052

Santa Cruz Biotechnology, Inc.

204734

Dayang Chem (Hangzhou) Co.,Ltd.

DC11784712

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CAS equal suppliers

Doxycyclinehyclate

Huateng Pharmaceutical Co.,Ltd

815518

AMPHOTERICIN-B (Oral/Parental)DOXYCYCLINE HCL

Ningbo Pangs Chem Co., Ltd.

NPC607524300

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1

Sirius Fine Chemicals SiChem GmbH

SC-0047

Prices & Availability

Data is processed

Properties for Doxycycline Hyclate

Molecular Weight:

462.45 g·mol−1

Melting point:

206-209 °C C (dec.)

Boiling point:

1250.6° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (50 mg/ml), DMSO (~1 mg/ml), methanol (1:4), and alcohol (1:60). Insoluble in chloroform.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

Hazard Symbols:

Storage temperature :

Store at +4 °C

Alternative Distributors of [Doxycycline Hyclate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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MSDS:

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