DRB | CAS 53-85-0 | Chemical-Suppliers

Element:

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C-S » Chemicals » drb-PX63766

Identification

DRB

CAS:

53-85-0

EINECS:

Molecular Formula:

C₁₂H₁₂Cl₂N₂O₄

MDL:

MFCD00036785

SMILES:

C1=C2C(=CC(=C1Cl)Cl)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

Synonym:

dbr ; drb ; nsc 401575 ; drb (benzimidazole) ; 5,6-dichlorobenzimidazole riboside ; dichlororibofuranosylbenzimidazole ; dichlorobenzimidazoleribofuranoside ; 5,6-dichlorobenzimidazoleriboside(drb) ; 5,6-dichlorobenzimidazole riboside 98% ; 5,6-dichlorobenzimidazole riboside (drb)98%

Description

DRB, an adenosine analogue, has been shown to reduce Uridine uptake in cells causing a premature termination of DNA transcription during the initiation phase. Mechanistic studies suggest that this compound acts as a mixed-type inhibitor with respect to casein kinase II and as a competitive inhibitor with respect to the nucleotide phosphate donor substrates. Experiments have noted that DRB can reversibly block germinal vesicle breakdown in bovine oocytes matured in vitro. DRB is an inhibitor of Cdk7, Cdk8 and Cdk9.

Suppliers

Santa Cruz Biotechnology, Inc.

200581

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CAS equal suppliers

5,6-Dichlorobenzimidazole riboside

Aea.ltd

A476952

5,6-Dichlorobenzimidazole riboside, 98%

Alfa (A Johnson Matthey Company)

A24967488

5,6-Dichlorobenzimidazole 1-beta-D-Ribofuranoside

TCI Chemicals (India) Pvt. Ltd.

D4292

Prices & Availability

Data is processed

Properties for DRB

Molecular Weight:

319.14 g·mol−1

Density:

~1.8 g/cm³ (Predicted)

Melting point:

222-224°C

Boiling point:

~606.2° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (>= 75 mM) without heating, ethanol (20 mg/ml) with heating at 60-65° C to obtain a clear colorless to pale yellow solution, DMF (100 mM), 1:2 DMF:PBS (pH 7.2) (0.3 mg/ml), and water. Somewhat soluble in methanol, and pyridine. Sparingly soluble in aqueous buffers.

Safety & Transport Information

Storage temperature :

-20°C

Alternative Distributors of [DRB]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences

Downloads

Mol File:

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MSDS:

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