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ErbB2 Inhibitor II

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Formula: C15H10N4O
CAS: 928207-02-7
search Element: inhibitor erbb2
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Identification

Structural Formula
ErbB2 Inhibitor II
CAS:
928207-02-7
EINECS:
Molecular Formula:
C15H10N4O
MDL:
SMILES:
C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=NNN=C3C#N
Synonym:


Description

Cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2. Reduces the phosphorylation of erbB2 in MDA-MB-453 cells, but not that of the over-expressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Has been shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.


Suppliers

Santa Cruz Biotechnology, Inc.
221592
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Prices & Availability




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Properties for ErbB2 Inhibitor II

Molecular Weight:
262.3 g·mol−1
Density:
1.37 g/cm3 (Predicted)
Melting point:
200.22° C (Predicted)
Boiling point:
517.6° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (50 mg/ml).
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Alternative Distributors of [ErbB2 Inhibitor II]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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