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D-erythro-MAPP

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Formula: C23H39 N O2
CAS: 143492-38-0
search Element: erythro mapp

Identification

Structural Formula
D-erythro-MAPP
CAS:
143492-38-0
EINECS:
Molecular Formula:
C23H39 N O2
MDL:
MFCD01076527
SMILES:
CCCCCCCCCCCCCC(=O)N[C@H](C)[C@H](C1=CC=CC=C1)O
Synonym:
d-erythro-mapp ; mapp, d-erythro ; (1s,2r)-d-erythro-2-(n-myristoylamino)-1-phenyl-1-propanol ; n-[(1r,2s)-2-hydroxy-1-methyl-2-phenylethyl]-tetradecanamide ; tetradecanamide,n-(2-hydroxy-1-methyl-2-phenylethyl)-, [s-(r*,s*)]- ; tetradecanamide,n-[(1r,2s)-2-hydroxy-1-methyl-2-phenylethyl]-


Description

D-erythro-MAPP is a synthetic analog of ceramide. Shown to selectively inhibit ASAH/APHC (alkaline ceramidase) both in vitro and in HL-60 cells (IC50 = 1-5 μM for ASAH/APHC (alkaline ceramidase) versus IC50 > 500 μM for acid ceramidase). D-erythro-MAPP's inhibition results in over 3-fold increase in endogenous ceramide in treated cells due to lack of breackdown of ceramide to sphingosine.


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Santa Cruz Biotechnology, Inc.
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L-erythro MAPP
Santa Cruz Biotechnology, Inc.
sc-205740

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Properties for D-erythro-MAPP

Molecular Weight:
361.5613 g·mol−1
Density:
0.965 g/cm3
Melting point:
82°C to 84°C
Boiling point:
536.7 °C at 760 mmHg
Flash point:
278.4 °C
Solubility:
0.5 mg/ml at 25.0 C in Water
Physical Description:
crystalline solid.
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Alternative Distributors of [D-erythro-MAPP]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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