Everolimus | CAS 159351-69-6 | Chemical-Suppliers

Element: everolimus

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C-S » Chemicals » everolimus-PX77122

Identification

Everolimus

CAS:

159351-69-6

EINECS:

Molecular Formula:

C₅₃H₈₃NO₁₄

MDL:

MFCD07785165

SMILES:

C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC

Synonym:

rad-001 ; everolimus, >=98% ; certican(r) ; everolimus ; certica ; certican ; everolimus api ; sdzrad ; zortress ; afinitor

Description

Everolimus is a macrolide derived from rapamycin with immunosuppressant properties shown to inhibit cell proliferation induced by growth factors. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Studies indicate that everolimus is a mTOR (FRAP) inhibitor that displays high affinity toward the intracellular receptor FKBP12. Additionally, the Everolimus-FKBP12 complex decreases the activity of the S6K1 and 4EBP by binding to FRAP.

Suppliers

Aea.ltd

A70140

Shandong SanYoung Industry Co., Ltd

SSI3501400

Ambeed, Inc.

A116645

H&Z Industry Co.,Ltd

HIC200800

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Shandong Ench Chemical Co.,Ltd

SECC3001500

Molcan Corporation

MC180540

Crystal Pharma (Gadea Grupo Farmacéutico)

CP4201680

Guangzhou Topwork Chemical Co., Ltd.

GTC3601440

Hangzhou Cherry Pharmaceutical Technology Co., Ltd.

HCPT5102550

Chemvon Biotechnology Co. Ltd.

CBC3001200

Alfa (A Johnson Matthey Company)

A320960

Daming Changda Co., Ltd.

DC240720

CSNpharm, Inc.

CSN16716

Hangzhou Keying Chem Co., Ltd.

HKC3001200

Hangzhou Lingrui Chemical Co., Ltd.

HLC3501400

Sigma-Aldrich International GmbH

SI320960

Finetech Industry Limited

FIL2501000

Carbone Scientific Co., Ltd.

CS280840

Pharmacore Co., Limited

PL230690

Hefei Hirisun Pharmatech Co., Ltd

HR011842

CM Fine Chemicals

CFC170680

Xingrui Industry Co., Limited

XIL2901160

Capot Chemical Co., Ltd.

20048

BOC Sciences

BS120360

Amadis Chemical Company Limited

ACCL3101550

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

218452

Get Quick Quote

CAS equal suppliers

RAD001

Aea.ltd

A4284

Everolimus-d4

Santa Cruz Biotechnology, Inc.

sc-218453

Everolimus; RAD001; SDZ-RAD

Excenen Pharmatech Co., Ltd.

EX-A2057

42-O-(2-Hydroxyethyl)-rapamycin

Salsbury Chemicals, Inc.

SC22326696

42-O-(2-Hydroxyethyl)-rapamycin

Gihi Chemicals Co., Limited

GCL251110044

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,1

BLD Pharmatech Ltd

BP122400367200

Prices & Availability

Data is processed

Properties for Everolimus

Molecular Weight:

958.232 g·mol−1

Density:

1.18 g/cm³ (Predicted)

Melting point:

Boiling point:

998.75° C at 760 mmHg (Predicted)

Solubility:

Soluble in chloroform, methanol, DMSO (100 mg/ml), water (<1 mg/ml at 25° C), and ethanol (100 mg/ml).

Hazard Statements

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36 - Irritating to eyes
R48/25 - Toxic: danger of serious damage to health by prolonged exposure if swallowed

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Symbols:

T, Xn, F

Storage temperature :

-20°C

Alternative Distributors of [Everolimus]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified