Y-27632, free base | CAS 146986-50-7

Element: 27632 base free

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C-S » Chemicals » free-base-PX17503

Identification

Y-27632, free base

CAS:

146986-50-7

EINECS:

Molecular Formula:

C₁₄H₂₁N₃O.2HCl

MDL:

MFCD03490488

SMILES:

C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N

Synonym:

Description

Y-27632, free base is the free base form of Y-27632 dihydrochloride, a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 also inhibits protein kinase C related kinase, PRK2.

Suppliers

Santa Cruz Biotechnology, Inc.

3536

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Prices & Availability

Data is processed

Properties for Y-27632, free base

Molecular Weight:

338.28025 g·mol−1

Solubility:

Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [Y-27632, free base]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | Shanghai Sun-shine Chemical Technology Co., Ltd. | ChengDu KaiXin Technology Development Co., Ltd. | BOC Sciences | Jinan Haohua Industry Co., Ltd.