J 104129 fumarate | CAS 244277-89-2

Element: fumarate 104129

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C-S » Chemicals » fumarate-PX72498

Identification

J 104129 fumarate

CAS:

244277-89-2

EINECS:

Molecular Formula:

C₂₄H₃₆N₂O₂.C₄H₄O₄

MDL:

MFCD09753272

SMILES:

CC(=CCCN1CCC(CC1)NC(=O)[C@@](C2CCCC2)(C3=CC=CC=C3)O)C.C(=CC(=O)O)C(=O)O

Synonym:

j 104129 fumarate ; (αr)-α-cyclopentyl-α-hydroxy-n-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamidefumarate ; (ar)-a-cyclopentyl-a-hydroxy-n-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate

Description

J 104129 is a potent mAChR M3 antagonist that displays ~ 120-fold selectivity over mAChR M2 (K_i values are 4.2, 19 and 490 nM for human mAChR M3, mAChR M1 and mAChR M2 receptors, respectively). J 104129 exhibits > 250-fold bronchial selectivity. It inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (K_B values are 3.3 and 170 nM for rat trachea mAChR M3 and rat right atria mAChR M2 receptors, respectively).