γ-CEHC

γ-CEHC is a β-oxidized metabolite of dietary γ-tocopherol that functions as a natriure hormone. It was initially characterized and purified from the urine of uremic patients, but it has since been found in urine from both those with congestive heart failure and control patients. γ-CEHC is also anti-inflammatory, reducing 8-isoprostane and inflammatory eicosanoid synthesis in rat models. The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements.