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GANT61

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Formula: C27H35N5
CAS: 500579-04-4
search Element: gant61
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Identification

Structural Formula
GANT61
CAS:
500579-04-4
EINECS:
Molecular Formula:
C27H35N5
MDL:
MFCD14635408
SMILES:
CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C
Synonym:


Description

GANT61 is a cell-permeable hexahydropyrimidine compound, shown to be an inhibitor of GLI-mediated gene transactivation. GLI-mediated transcription is the final step in the Hedgehog (Hh) signaling pathway, therefore GANT61 halts hedgehog pathway effects. Sonic hedgehog, a homolog of Hedgehog is essential for proper embryonic development and the interference of GANT61 with its production could lead to potential developmental issues. Additionally, this compound was found to successfully inhibit proliferation of tumor cells in vitro in a GLI-dependent manner. GANT61 is an inhibitor of GLI-1 and GLI-2.


Suppliers

Aea.ltd
A4284
+
Simagchem Corporation
SC126378
+
BOC Sciences
BS72216
+
Santa Cruz Biotechnology, Inc.
202630
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CAS equal suppliers

GANT 61
Ambeed, Inc.
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CSNpharm, Inc.
CSN15989
GANT-61
Excenen Pharmatech Co., Ltd.
EX-A339
2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline)
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC116180
2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline)
BLD Pharmatech Ltd
BP2246467392
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine]
Leap Chem Co., Ltd
LC2340070200
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine]
Finipharma Ltd
F1820036400
2-[[3-[[2-(Dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-n,n-dimethylaniline
Angene International Limited
AGN-PC-0JR0YE

Prices & Availability




Data is processed


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Properties for GANT61

Molecular Weight:
429.60 g·mol−1
Density:
1.14 g/cm3
Boiling point:
549.00° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (5 mg/ml), ethanol (5 mg/ml), and 1:3 EtOH:PBS(PH 7.2) (0.25 mg/ml).
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Safety & Transport Information

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Alternative Distributors of [GANT61]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | D&P Global Chemical Co., Ltd

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MSDS:
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